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5 Pieces of Information on Diabetes that Everyone Needs to Know
If you or someone you love has been diagnosed with diabetes, it
can be scary with all of the conflicting information on diabetes
that is currently available. While the internet can yield some
great information, there is also a lot of wrong...
Diabetes: The $132 Dollar Pandemic
You know, it's not everyday a fellow like me gets to announce a
major paradigm shift, much less concerning diabetes ...or any
other medical condition.
You don't know what a paradigm shift is? Well, if I mentioned
events and names...
Diabetic Gains From Nutritious Whole Grains
My mother was a diabetic and when she was diagnosed, it was called adult onset diabetes. Do you know why they changed the name to type 2? I'm afraid the sad truth is it can no longer be called "adult," because the deadly type 2 diabetes is now...
Pre Diabetic
Did you know that you can be 'just a little bit diabetic'? The condition is technically called 'pre diabetes', and it is characterized by persistent high blood sugar levels. Left untreated, over 50% of those diagnosed with pre diabetes will...
Take Control of Diabetes by Avoiding these 5 Common Mistakes
(ARA) - If you are one of the 17 million people in the United States who has diabetes, you know that careful monitoring of your blood sugar and ongoing treatment are critical to your health. By keeping your blood sugar as close to normal as...
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Combination of Thiazide-Type Diuretic and Beta-Blocker may Cause Diabetes
Clinical Question: In patients with hypertension is it safe to combine thiazide-type diuretic and beta-blocker?
Bottom Line: Studies suggest that the routine combined use of a thiazide with a beta-blocker should be questioned in the early management of hypertension, particularly in patients who are at increased risk of developing new-onset diabetes. In such patients, the increased risk of developing diabetes may exceed the benefit of blood pressure lowering.
Reference: J Hypertens. 2005 Oct;23(10):1777-1781
Study Design: Retrieve randomized control trials and meta-analysis
Synopsis: Recently published trials addressing the pharmacological management of hypertension have reported an increase in new-onset diabetes mellitus when comparing certain older and newer treatment regimens. Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified. So randomized control trials were retrieved that: (i) featured stepped treatment to manage hypertension; (ii) compared initial treatment using a thiazide or beta-blocker (older drug) with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or calcium antagonist (newer drug); (iii) assessed cardiovascular outcomes; (iv) reported new-onset diabetes; and (v) provided at least 1-year follow-up. A meta-analysis of available trials indicated that patients exposed to treatment regimens combining thiazides and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination of drugs (risk ratio for alternative therapy 0.81, 95% confidence interval 0.77-0.86). Current data cannot inform reliably about the risks associated with individual older drugs because of similar overall exposures in patients starting on newer and older drugs.
About the Author
A Certified Family Physician of the Philippine Academy of Family Physician and continue to complete the requirements for Continuing Medical Education in Family Practice. Also a member of the Philippine Medical Informatics Society, Philippine Occupational Health and Safety Inc., and Pangasinan Medical Society.
Faculty Department of Physiology (Medicine) Lyseum- Northwestern University, Dagupan, Pangasinan, Faculty Medical Informatics Lyseu
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